RESUMEN
The surface of the eye is directly exposed to the external environment, protected only by a thin tear film, and may therefore be damaged by contact with ambient particulate matter, liquids, aerosols, or vapors. In the workplace or home, the eye is subject to accidental or incidental exposure to cleaning products and pesticides. Organic matter may enter the eye and cause infection. Ocular surface damage can trigger a range of symptoms such as itch, discharge, hyperemia, photophobia, blurred vision, and foreign body sensation. Toxin exposure can be assessed clinically in multiple ways, including via measurement of tear production, slit-lamp examination, corneal staining, and conjunctival staining. At the cellular level, environmental toxins can cause oxidative damage, apoptosis of corneal and conjunctival cells, cell senescence, and impaired motility. Outcomes range from transient and reversible with complete healing to severe and sight-compromising structural changes. Classically, evaluation of tolerance and safety was carried out using live animal testing; however, new in vitro and computer-based, in silico modes are superseding the gold standard Draize test. This review examines how environmental features such as pollutants, temperature, and seasonality affect the ocular surface. Chemical burns to the eye are considered, and approaches to protect the ocular surface are detailed.
RESUMEN
Traumatic Brain Injury (TBI) is a major global public health problem. Neurological damage from TBI may be mild, moderate, or severe and occurs both immediately at the time of impact (primary injury) and continues to evolve afterwards (secondary injury). In mild (m)TBI, common symptoms are headaches, dizziness and fatigue. Visual impairment is especially prevalent. Insomnia, attentional deficits and memory problems often occur. Neuroimaging methods for the management of TBI include computed tomography and magnetic resonance imaging. The location and the extent of injuries determine the motor and/or sensory deficits that result. Parietal lobe damage can lead to deficits in sensorimotor function, memory, and attention span. The processing of visual information may be disrupted, with consequences such as poor hand-eye coordination and balance. TBI may cause lesions in the occipital or parietal lobe that leave the TBI patient with incomplete homonymous hemianopia. Overall, TBI can interfere with everyday life by compromising the ability to work, sleep, drive, read, communicate and perform numerous activities previously taken for granted. Treatment and rehabilitation options available to TBI sufferers are inadequate and there is a pressing need for new ways to help these patients to optimize their functioning and maintain productivity and participation in life activities, family and community.
RESUMEN
Driving is a highly visual task, yet the vision requirements for driving licensure vary widely. All US states have a threshold for visual acuity (e.g. most use 20/40 for an unrestricted license). Contrast sensitivity (CS) is not measured for licensure, despite evidence that it may be a better predictor of crash risk than visual acuity (VA). Two experiments were conducted to investigate how simulated reductions in VA and CS affect the detection of pedestrians in a driving simulator during the daytime in a highway setting. Young normally-sighted current drivers wore goggles simulating different levels of VA and CS loss (within a range that would meet licensing criteria) and pressed the horn as soon as they saw a pedestrian. The proportion of pedestrians detected and driving speed was not different between the conditions. Reducing VA alone did not significantly reduce reaction time or the deceleration needed to stop before the collision point. However, adding a CS loss to a VA deficit increased both reaction time and the deceleration required to stop before the collision point. These results suggest that an individual's CS should be considered when determining visual fitness to drive, especially in the early stages of ocular disease, such as cataract, where CS may be impaired while high contrast VA is still relatively unimpaired.
